BACKGROUND
There is growing evidence that unfavorable neighborhood contexts may influence prostate cancer (CaP) progression. Whether these associations may be explained in part by differences in tumor-level somatic alterations remain unclear.
METHODS
Data on tumor markers (PTEN, p53, ERG, and SPINK1) were obtained from 1,157 participants with CaP in the Health Professionals Follow-up Study. Neighborhood greenness, socioeconomic status, and the income Index of Concentration at Extremes were obtained from satellite and Census data and linked to participants' address at diagnosis and at study enrollment. Exposures were scaled to an interquartile range and modeled as tertiles. Bivariate associations between tertiles of neighborhood factors and tumor markers were assessed in covariate adjusted logistic regression models to estimate odds ratios and 95% confidence intervals.
RESULTS
There was no association between any of the neighborhood contextual factors and PTEN, p53, ERG, or SPINK1 in bivariate or multivariable adjusted models. Results were generally consistent when modeling exposure using exposure at diagnosis or at study enrollment.
DISCUSSION
In this multilevel study of men with CaP, we found no evidence of associations between neighborhood context and tumor tissue markers.
IMPACT
Our results provide some of the first empirical data in support of the hypothesis that CaP risk conferred by tumor tissue markers may arise independently of underlying neighborhood context. Prospective studies in more diverse populations are needed to confirm these findings.