BACKGROUND
Many states have laws requiring mammography facilities to tell women with dense breasts and negative results on screening mammography to discuss supplemental screening tests with their providers. The most readily available supplemental screening method is ultrasonography, but little is known about its effectiveness.
OBJECTIVE
To evaluate the benefits, harms, and cost-effectiveness of supplemental ultrasonography screening for women with dense breasts.
DESIGN
Comparative modeling with 3 validated simulation models.
DATA SOURCES
Surveillance, Epidemiology, and End Results Program; Breast Cancer Surveillance Consortium; and medical literature.
TARGET POPULATION
Contemporary cohort of women eligible for routine screening.
TIME HORIZON
Lifetime.
PERSPECTIVE
Payer.
INTERVENTION
Supplemental ultrasonography screening for women with dense breasts after a negative screening mammography result.
OUTCOME MEASURES
Breast cancer deaths averted, quality-adjusted life-years (QALYs) gained, biopsies recommended after a false-positive ultrasonography result, and costs.
RESULTS OF BASE-CASE ANALYSIS
Supplemental ultrasonography screening after a negative mammography result for women aged 50 to 74 years with heterogeneously or extremely dense breasts averted 0.36 additional breast cancer deaths (range across models, 0.14 to 0.75), gained 1.7 QALYs (range, 0.9 to 4.7), and resulted in 354 biopsy recommendations after a false-positive ultrasonography result (range, 345 to 421) per 1000 women with dense breasts compared with biennial screening by mammography alone. The cost-effectiveness ratio was $325,000 per QALY gained (range, $112,000 to $766,000). Supplemental ultrasonography screening for only women with extremely dense breasts cost $246,000 per QALY gained (range, $74,000 to $535,000).
RESULTS OF SENSITIVITY ANALYSIS
The conclusions were not sensitive to ultrasonography performance characteristics, screening frequency, or starting age.
LIMITATION
Provider costs for coordinating supplemental ultrasonography were not considered.
CONCLUSION
Supplemental ultrasonography screening for women with dense breasts would substantially increase costs while producing relatively small benefits.
PRIMARY FUNDING SOURCE
National Cancer Institute.