The rise of antibiotic resistance is a major threat to the practice of medicine and is driven in large part by overuse of antibiotics. In his latest study, Institute Lecturer Sanjat Kanjilal, MD, MPH, and team take on this issue by showing how large-scale machine learning models can be applied to observational electronic health record data to predict antibiotic resistance, make treatment recommendations, and build patient-level and public health models to aid in decision support. We spoke with Dr.