Precision Medicine Translational Research Center (PROMoTeR)

Genomic testing has gained enthusiasm for its ability to identify individuals with undiagnosed genetic conditions, provide information about risks for future disease, and improve medication decisions. Evidence to date is limited, however, about the medical, behavioral, and economic impact of genomic testing in healthy populations. PROMoTeR Center faculty are addressing this evidence gap using a combination of observational studies, randomized trials, and decision analytic models.

We focus on the heterogeneity and pathophysiology of gestational diabetes to advance knowledge towards targeted approaches to prevent, diagnose, and treat gestational diabetes in the hope to improve health of both mothers and offspring.

We develop novel genomic medicine interventions and use implementation science and comparative effectiveness methods to evaluate intervention outcomes that are important to patients and families and to the health care system. 

We develop and apply statistical methods to determine and understand the path from gene to disease and the role of the environment using causal inference, mediation analysis, Mendelian randomization, machine learning, and computational statistics.