We studied healthy infant feeding practices among 308 mother-infant pairs including exclusive breastmilk, satiety cues, complementary food introduction, sugary beverage intake, and bottle use in bed. We examined associations of individual and cumulative infant feeding practices through 12 months of age with body mass index (BMI) z-score at 2 years. Exclusive breastmilk, and avoidance of bottle use in bed, were associated with lower BMI z-score (β -0.29 units; 95% CI, -0.56, -0.02 units and β -0.32 units; 95% CI, -0.57, -0.07, respectively), when accounting for maternal pre-pregnancy BMI, household income, infant sex, race, and ethnicity. Adherence to 4-5 practices, compared to ≤ 2 practices, was associated with lower BMI z-score (β -0.84 units; 95% CI, -1.35, -0.34 units). Adherence to healthy infant feeding practices may reduce risk of excessive adiposity in early childhood. Targeting multiple infant feeding practices may be a more effective way to prevent childhood adiposity. An infographic is available for this article at: http://links.lww.com/MPG/C826.